I am going to pick up an old thought experiment. Assume that 616 Marvel had real time pass, using 1984 as the zero point.
Current Marvel would more or less match up with the end of G1 in 1991. (And, if "Age of Ultron" plays out as expected, there might not be much happening after "1991".) The only real issue would be striking real-life references from the comics. But, those are problematic regardless of crossovers.
Assuming that 1984 is the "zero point", (where real-time and page time meet), Marvel's TF run (set roughly in real time) and 616 Marvel time (page time) would intersect roughly as follows:
1984: Autobots and Decepticons awaken. Circuit Breaker begins quest for revenge against all robots. Blackrock allies with Autobots. Marvel heroes engaged in "Secret War" on Beyonder's battle world. Savage Land destroyed. Tony Stark retakes Iron Man identity from Jim Rhodes, defeats Obidia "Iron Monger" Stane and starts the "Armor Wars". Spider-Man acquires and disposes of the alien costume. Kraven the Hunter Commits Suicide. Secret Wars II and death of the Beyonder.
1985: Autobots/Decepticon war escalates. Year of the Scourge (arguably a "real time" year). DareDevil is "Born Again". John Walker become Captain America and later USAgent. Original X-Men form X-Factor. Fall of the Mutants. Inferno. Byrne's run on "West Coast Avengers" opens with the Vision destroyed. Scarlett Witch bears children through force of delusion and has psychotic breakdown in part due to Immortus' scheming.
1986: Optimus Prime destroyed. Megatron lost. Grimlock and Ratbat take leadership roles. RAAT is formed. "Carwash of Doom". Revlon era Marvel: Executioner's Song, x-teams significantly re-organized. Peter David run on Hulk is in full swing. Various "Crossing" storylines in "Avengers". Ben Reilly returns. Los Angeles riots (as depicted in "Nomad") occur. (And, that is only one reason why including real events in comics is problematic.) Infinity Gauntlet, Infinity War and Infinity Crusade. Galactic Storm, destructiion of the Kree Empire. "Sabertooth: Deathhunt" happens, and is even more awesome.... West Coast Avengers disband and re-unite as Force Works. Rhodes becomes War Machine.
1987: Fortress Maximus's contingent arrives on Earth. Spike merges with Maximus. Professor X has a mental breakdown, contributing to the manifestation of Onslaught. Many of Earth's heroes sent to an alternate world. Rise of Zemo's first team of Thunderbolts. Earth's heroes return from alternate Earth.
1988: Optimus Prime returns as a Power Master. Starscream acquires the Underbase. Autobots engage in holding actions on Earth. Morrison's "X-Men" run, Xorn et al. Busiek's and John's "Avengers" run. Norman Osborn's children with Gwen Stacy revealed. Spider-Man is revealed as a spider-avatar....oh my....
1989: Furman's run begins. Megatron returns. Ratchet lost. Grimlock, Bumblebee, Jazz and Starscream return. Bendis begins on "Avengers", "Disassembeld". Tony Stark injecte with "Extremis" tech. Sentry returns. Superhuman "Civil War". Steve Rogers seemingly killed.
1990: Matrix Quest begins as Unicron approaches. Formation of the Neo Knights. "Civil War" ends. (Arguable, "Civil War" was published in real time, which is problematic on this listing.) Skrull Secret Invasion revealed. Normal Osborn Osborn's Dark Reign begins and ends with the Seige of Asgard. Steve Rogers returns. Death of the Sentry. (The Sentry's death could arguably be used to reconcile some of the problems inherent with setting Marvel to externally real time.) Heroic Age begins on Earth.
1991: Transformers and Neo Knights leave Earth to battle Unicron. Grimlock returns with nucleon, creating Action Masters. Ark (re)crashes on Earth, Galvatron is defeated by Fortress Maximus. Decepticon army broken on Klo. Avengers and X-Men battle over Phoenix force. Kaine takes mantle of new Scarlet Spider. ???????????
And, if we use the IDW/Marvel cross-over, 2006 would be the zero point.
Dom
-notes that "All Hail Megatron" would have been a much different story set in 616 Marvel.